A numerical approach for detecting switch-like bistability in mass action chemical reaction networks with conservation laws

Abstract Background Theoretical analysis of signaling pathways can provide a substantial amount of insight into their function.One particular area of research considers signaling pathways capable of assuming two or more stable states given the same amount of signaling ligand.This phenomenon of bistability can give rise to switch-like behavior, a me

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Computer Vision-Based Assessment of Motor Functioning in Schizophrenia: Use of Smartphones for Remote Measurement of Schizophrenia Symptomatology

Introduction: Motor abnormalities have been shown to be a distinct component of schizophrenia COLLAGEN ORANGE symptomatology.However, objective and scalable methods for assessment of motor functioning in schizophrenia are lacking.Advancements in machine learning-based digital tools have allowed for automated and remote “digital phenotyping” of

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